Alfredo Chicken Zucchini Casserole

Featured in: Hearty Dinners

This creamy Alfredo chicken zucchini casserole features sautéed zucchini and onion, tender cooked chicken, and a rich blend of Alfredo sauce and cheeses. Baked until golden and bubbly, it's simple to prepare and perfect for family dinner or meal prep. With easy gluten-free modifications, it's both comforting and versatile. A delicious low-carb option loaded with protein and vegetables, finished with fresh parsley.

Updated on Fri, 24 Oct 2025 17:47:32 GMT
Cheesy Alfredo Chicken Zucchini Casserole: golden bubbly topping and creamy, satisfying layers. Save It
Cheesy Alfredo Chicken Zucchini Casserole: golden bubbly topping and creamy, satisfying layers. | sunnyspoonful.com

This rich and creamy Alfredo Chicken Zucchini Casserole delivers all the comforts of your favorite Italian-inspired dish, but with a fresh veggie twist It is my go-to when I crave something cozy but also want a lighter low carb dinner Everyone always asks for seconds when I bring this to family get-togethers and the leftovers are just as tasty for easy meal prep

The first time I baked this, it surprised me how the zucchini and Alfredo sauce melded into such a comforting combination Now my sister always texts for the recipe each time zucchini are in season

Ingredients

  • Chicken breast: provides lean satisfying protein I use home-cooked or rotisserie for extra flavor
  • Fresh zucchini: brings moisture and mild flavor For optimal results pick firm small to medium zucchini with glossy skin
  • Onion and fresh garlic: build a savory base Choose yellow onion for its sweetness and always chop garlic right before cooking for boldness
  • Alfredo sauce: makes the casserole creamy and indulgent For best flavor select a brand you trust or use your favorite homemade version Read labels if you need gluten free
  • Sour cream: gives a tangy boost and extra silkiness Whole fat versions will give you the most luxurious texture
  • Mozzarella cheese: creates that irresistible bubbly topping Shred it yourself for the best melt
  • Parmesan cheese: delivers saltiness and depth Always grate fresh if you can for great flavor
  • Dried Italian herbs: infuse each bite with warmth Seek out a blend with oregano basil and thyme
  • Salt and black pepper: round out the flavors Taste your Alfredo sauce before adding more salt
  • Chopped fresh parsley for garnish: is optional but adds fresh color Pick flat leaf for best aroma

Instructions

Preheat the Oven:
Set your oven to 375 degrees Fahrenheit or 190 degrees Celsius Lightly grease a nine by thirteen inch casserole dish so the casserole does not stick and clean up stays easy
Sauté the Aromatics:
Warm a large skillet over medium heat Swirl in just enough olive oil to lightly coat the surface Add chopped onions and let them cook slowly for about three minutes Stir occasionally so they soften evenly Once onions turn translucent sprinkle in the minced garlic Stir and cook for one more minute just until the kitchen smells wonderful but before the garlic browns
Cook the Zucchini:
Add the zucchini slices to the skillet and toss with the aromatics Let them cook for about five minutes stirring now and then You want them tender but still holding their shape Avoid letting them get soggy since they will bake more later Remove skillet from the heat
Build the Casserole Base:
In a large mixing bowl gently combine your cooked chicken cubes sautéed zucchini and onions Alfredo sauce sour cream dried Italian herbs salt and pepper Stir everything together so chicken and vegetables are coated without breaking up the zucchini slices
Layer and Top:
Spoon the mixture into your greased casserole dish and spread it out evenly Sprinkle mozzarella cheese across the entire surface then add the Parmesan on top This layering gets you those beautiful browned cheesy spots
Bake to Golden Perfection:
Place the dish uncovered in your preheated oven Bake for twenty five to thirty minutes You will know it is done when the casserole is bubbling hot and the cheese turns golden with the edges just a bit crisp
Rest and Garnish:
Pull the dish from the oven Let it rest for five minutes before serving This helps the casserole set and makes serving easier Scatter chopped parsley over the top for a pop of fresh color and aroma
Baked Alfredo Chicken Zucchini Casserole, ready-to-eat, showcasing golden-brown cheese and parsley garnish. Save It
Baked Alfredo Chicken Zucchini Casserole, ready-to-eat, showcasing golden-brown cheese and parsley garnish. | sunnyspoonful.com

My favorite part of this dish is how the Alfredo sauce soaks into the zucchini making each bite ultra creamy When I tested this with my cousin she admitted she forgot there were vegetables in it A true win for picky eaters

Storage Tips

Once fully cooled cover and store casserole leftovers in an airtight container in the fridge They will stay fresh up to three days Reheat in the oven at three hundred twenty five degrees until hot or microwave in single portions

Ingredient Substitutions

Rotisserie chicken works well if you are short on time Or use cooked turkey for a post holiday twist If you are not a fan of zucchini try thinly sliced yellow squash For a dairy free version substitute coconut cream for the sour cream and opt for a vegan Alfredo

Serving Suggestions

Serve warm as the centerpiece of dinner alongside a vibrant green salad For a heartier plate add roasted sweet potatoes or serve with gluten free bread When I cook for friends I like to put an extra dish of freshly grated Parmesan on the table

Cultural and Seasonal Notes

This casserole takes inspiration from both Italian Alfredo and classic American bakes making it feel familiar and comforting It is especially fitting when summer zucchini are abundant at the farmers market but I find it plenty cozy in cooler months too

Seasonal Adaptations

Sprinkle in fresh basil or oregano from the garden for a summery touch Add shredded cooked spinach to boost the greens in winter Toss in a handful of sliced mushrooms for more depth and earthiness

Success Stories

This casserole has saved many weeknights for me and my neighbors My friend once doubled the recipe for a family reunion and it disappeared in minutes If you meal prep it on Sunday lunch boxes will thank you all week

Freezer Meal Conversion

To freeze assemble the casserole without baking then wrap tightly in foil and freeze up to two months When ready to eat bake straight from frozen at three hundred fifty degrees until heated through and bubbling about fifty minutes

Warm and comforting Alfrеdo Chicken Zucchini Casserole bake bubbling, fragrant, a weeknight delight. Save It
Warm and comforting Alfrеdo Chicken Zucchini Casserole bake bubbling, fragrant, a weeknight delight. | sunnyspoonful.com

This casserole is perfect for sharing Whether for weeknight family dinners or meal prepping, it's sure to disappear fast Savory, creamy, and packed with veggies for a win every time

Recipe FAQs

Can I use turkey instead of chicken?

Absolutely! Substitute equal amounts of cooked turkey for chicken in the dish for similar flavor and texture.

How do I make this casserole gluten-free?

Ensure your Alfredo sauce is certified gluten-free and check all other ingredients for hidden gluten sources.

Can I add more vegetables?

Yes. Try adding sliced mushrooms or baby spinach during sautéing for extra color and nutrition.

Do I need to pre-cook the chicken?

Yes, use cooked chicken breast—either roasted, poached, or leftover—for best results. Shred or cube before mixing.

How do I get a golden cheesy top?

Bake uncovered and use a mix of mozzarella and Parmesan cheese. If desired, broil for a minute after baking.

What sides go well with this dish?

Pair with a crisp green salad or gluten-free bread for a balanced, satisfying meal.

Alfredo Chicken Zucchini Casserole

Creamy Alfredo sauce, chicken and zucchini baked to golden perfection for a comforting main dish.

Prep Time
20 mins
Cook Time
35 mins
Total Duration
55 mins
Authored by Lana Bright

Recipe Type Hearty Dinners

Skill Level Easy

Cuisine Style American Italian-inspired

Recipe Yield 4 Serving Size

Diet Preferences Free From Gluten, Low Carbohydrate

What You'll Need

Proteins

01 2 cups cooked chicken breast, cubed or shredded (about 2 medium chicken breasts)

Vegetables

01 3 medium zucchinis, sliced into 1/4-inch rounds
02 1 small onion, finely chopped
03 2 cloves garlic, minced

Sauce

01 1 1/2 cups Alfredo sauce (store-bought or homemade; gluten-free if needed)
02 1/2 cup sour cream

Cheese

01 1 cup shredded mozzarella cheese
02 1/2 cup grated Parmesan cheese

Seasonings

01 1/2 teaspoon dried Italian herbs
02 1/4 teaspoon salt
03 1/4 teaspoon black pepper

Optional Garnish

01 2 tablespoons chopped fresh parsley

Directions

Step 01

Preheat and Prepare Bakeware: Preheat oven to 375°F (190°C). Lightly grease a 9x13-inch casserole dish with cooking spray or butter.

Step 02

Sauté Aromatics: In a large skillet over medium heat, warm a splash of olive oil. Add chopped onion and sauté for 3 minutes until translucent. Stir in minced garlic and cook for an additional minute.

Step 03

Cook Zucchini: Add sliced zucchini to the skillet and cook for 5 minutes, stirring occasionally, until just tender but not overly soft. Remove skillet from heat.

Step 04

Combine Main Components: In a large mixing bowl, gently combine cooked chicken, sautéed vegetables, Alfredo sauce, sour cream, dried Italian herbs, salt, and black pepper until evenly distributed.

Step 05

Layer and Top: Transfer mixture to the prepared casserole dish, spreading evenly. Sprinkle mozzarella and Parmesan cheese over the top.

Step 06

Bake to Finish: Bake uncovered for 25 to 30 minutes, allowing the casserole to bubble and cheese to develop a golden-brown crust.

Step 07

Rest and Garnish: Remove from oven and let rest for 5 minutes. Garnish with chopped parsley prior to serving for a fresh finish.

Tools You'll Need

  • 9x13-inch casserole dish
  • Large skillet
  • Mixing bowl
  • Chef’s knife
  • Cutting board
  • Wooden spoon or spatula

Allergy Information

Review each ingredient to identify potential allergens, and consult a healthcare professional if you're unsure.
  • Contains dairy: Alfredo sauce, sour cream, mozzarella cheese, Parmesan cheese.
  • Potential gluten exposure: verify Alfredo sauce ingredients if sensitive or celiac.
  • Contains milk proteins.
  • Always check product labels for hidden allergens.

Nutrition Details (Per Serving)

This nutritional data is for reference only and isn't a substitute for medical advice.
  • Caloric Value: 410
  • Fats: 25 grams
  • Carbohydrates: 10 grams
  • Proteins: 36 grams