Baked Pesto Chicken Mac & Cheese

Featured in: Hearty Dinners

This satisfying casserole combines tender, herb-seasoned chicken tossed in vibrant basil pesto with perfectly cooked macaroni enveloped in a rich, three-cheese béchamel sauce. The bubbly, golden panko-Parmesan crust adds delightful crunch to every bite.

Ideal for feeding a family or meal prep, this American-Italian fusion dish delivers comforting flavors with restaurant-quality results. The creamy mozzarella, sharp cheddar, and savory Parmesan create layers of cheesy goodness while the pesto adds fresh, aromatic brightness.

Baking everything together allows the flavors to meld beautifully, resulting in a hearty main that's both impressive and approachable.

Updated on Mon, 02 Feb 2026 08:38:00 GMT
Freshly baked Baked Pesto Chicken Mac & Cheese bubbling in a dish, featuring golden panko topping and a wooden serving spoon ready to scoop. Save It
Freshly baked Baked Pesto Chicken Mac & Cheese bubbling in a dish, featuring golden panko topping and a wooden serving spoon ready to scoop. | sunnyspoonful.com

My son walked into the kitchen one evening and asked if we could make mac and cheese, but better. I had leftover pesto in the fridge and some chicken breasts thawing, so I threw them together in a casserole dish without much of a plan. The smell that filled the house an hour later made everyone gather around the oven door, waiting. It's been our go-to comfort meal ever since.

I made this for a potluck once, and three people asked for the recipe before we even finished eating. One friend later told me her kids, who normally refuse anything green, devoured it without complaint. There's something about the pesto blending into the cheese sauce that makes it less intimidating and more inviting. It's become my secret weapon for feeding picky eaters and impressing guests at the same time.

Ingredients

  • Elbow macaroni (400 g): The classic shape holds the cheese sauce perfectly in every bite, and cooking it just to al dente ensures it won't turn mushy during baking.
  • Boneless, skinless chicken breast (500 g): Cut into bite-sized pieces so they cook quickly and distribute evenly throughout the casserole.
  • Olive oil (2 tbsp for chicken, 1 tbsp for topping): Helps the chicken brown nicely and binds the panko topping so it crisps up in the oven.
  • Salt, black pepper, dried Italian herbs: Simple seasonings that bring out the chicken's flavor without competing with the pesto.
  • Basil pesto (100 g): The star ingredient that gives the chicken a fragrant, herby coating and adds brightness to the whole dish.
  • Unsalted butter (3 tbsp): Forms the base of the roux for a silky cheese sauce that coats every noodle.
  • All-purpose flour (3 tbsp): Thickens the milk into a luscious sauce, just whisk it constantly to avoid lumps.
  • Whole milk (700 ml): Creates a rich, creamy sauce that's not too heavy, and whole milk keeps it from separating in the oven.
  • Mozzarella cheese (150 g): Melts beautifully and adds that stretchy, gooey texture everyone loves.
  • Parmesan cheese (100 g shredded, 30 g for topping): Brings a sharp, nutty depth that balances the creaminess of the other cheeses.
  • Sharp cheddar cheese (100 g): Adds a tangy bite and classic mac and cheese flavor that feels familiar and comforting.
  • Garlic powder (1/2 tsp): A subtle background note that enhances the savory richness without overpowering the pesto.
  • Panko breadcrumbs (40 g): Creates a light, crunchy topping that turns golden and irresistible in the oven.

Instructions

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Prep your oven and dish:
Preheat your oven to 200°C (400°F) and grease a large baking dish, about 23x33 cm. This ensures nothing sticks and cleanup stays easy.
Cook the macaroni:
Bring a large pot of salted water to a boil, then cook the macaroni until al dente according to package directions. Drain well and set aside, letting it steam dry a bit so it absorbs the sauce better.
Sear and season the chicken:
Heat 2 tablespoons of olive oil in a skillet over medium heat, add the chicken pieces, and season with salt, pepper, and Italian herbs. Cook for 6 to 8 minutes until golden and cooked through, then remove from heat and toss with the basil pesto until every piece is coated.
Make the cheese sauce:
In a large saucepan, melt the butter over medium heat, whisk in the flour, and cook for about a minute until it smells nutty. Gradually whisk in the milk, stirring constantly, until the mixture thickens into a smooth sauce after 4 to 5 minutes.
Stir in the cheeses:
Remove the saucepan from heat and stir in the mozzarella, Parmesan, cheddar, and garlic powder until melted and creamy. Taste and adjust the seasoning with salt and pepper as needed.
Combine everything:
In a large mixing bowl, gently combine the cooked macaroni, cheese sauce, and pesto chicken, folding until everything is evenly coated. Spoon the mixture into your prepared baking dish, spreading it out evenly.
Prepare the topping:
In a small bowl, mix together the panko breadcrumbs, grated Parmesan, and 1 tablespoon of olive oil until the crumbs are lightly coated. Sprinkle this mixture evenly over the top of the casserole.
Bake until golden:
Place the dish in the oven and bake for 20 to 25 minutes, until the casserole is bubbling around the edges and the topping is golden brown and crispy. Let it rest for 5 minutes before serving so the sauce can set slightly.
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Easily spray or drizzle oil for roasting vegetables, air frying, sautéing, and dressing salads with controlled coverage.
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A close-up of creamy Baked Pesto Chicken Mac & Cheese, highlighting tender chicken pieces, green pesto swirls, and melted mozzarella cheese strings. Save It
A close-up of creamy Baked Pesto Chicken Mac & Cheese, highlighting tender chicken pieces, green pesto swirls, and melted mozzarella cheese strings. | sunnyspoonful.com

One night, my daughter set the table without being asked while this was baking, and my husband poured glasses of water for everyone. We all sat down together, something that doesn't happen as often as I'd like, and talked about our day while passing around second helpings. That's when I realized this dish had become more than dinner, it was the reason we slowed down and gathered as a family.

Make-Ahead and Storage Tips

You can assemble the entire casserole up to a day ahead, cover it tightly with foil, and refrigerate until you're ready to bake. Just add an extra 5 to 10 minutes to the baking time if you're starting from cold. Leftovers keep well in an airtight container in the fridge for up to three days, and I've had great success reheating individual portions in the microwave with a splash of milk to loosen the sauce. If you want to freeze it, do so before baking, then thaw overnight in the fridge and bake as directed.

Flavor Variations to Try

I've swapped the basil pesto for sun-dried tomato pesto when I wanted something a bit sweeter and tangier, and it was fantastic. Adding a handful of sautéed spinach or kale to the mixture boosts the nutrition and adds pretty green flecks throughout. You could also stir in some cherry tomatoes or roasted red peppers for pops of color and flavor. If you're feeling adventurous, try mixing in a little smoked gouda or fontina in place of some of the cheddar for a smokier, more complex taste.

Serving Suggestions and Pairings

This casserole is rich and filling, so I like to serve it with a crisp green salad dressed in lemon vinaigrette to cut through the creaminess. Garlic bread or a warm baguette is perfect for mopping up any extra cheese sauce on your plate. A glass of chilled Sauvignon Blanc or a light Pinot Grigio pairs beautifully with the pesto and cheese.

  • Try serving it alongside roasted broccoli or green beans for a complete meal.
  • Leftover casserole makes an excellent lunch the next day, just reheat gently with a drizzle of milk.
  • If you're feeding a crowd, double the recipe and use two baking dishes so everyone gets plenty.
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Golden-crusted Baked Pesto Chicken Mac & Cheese served in a white dish, steam rising, ready for a family weeknight dinner with salad. Save It
Golden-crusted Baked Pesto Chicken Mac & Cheese served in a white dish, steam rising, ready for a family weeknight dinner with salad. | sunnyspoonful.com

This casserole has earned a permanent spot in our weekly rotation, and I hope it does the same for you. There's something deeply satisfying about pulling a bubbling, golden dish from the oven and watching everyone's face light up.

Recipe FAQs

Can I make this ahead of time?

Yes, assemble the entire casserole up to 24 hours ahead, cover tightly, and refrigerate. Add 5-10 minutes to baking time if baking cold. You can also freeze it unbaked for up to 3 months.

What other cheeses work well in this dish?

Fontina adds excellent meltiness, smoked gouda brings depth, Gruyère offers nutty notes, or provolone provides mild creaminess. Mix up to three varieties for complex flavor profiles.

How do I prevent the topping from getting too dark?

Check after 15 minutes of baking. If browning too quickly, loosely tent with foil. Remove foil during the last 5 minutes to maintain crispiness.

Can I use different pasta shapes?

Shells, cavatappi, or penne capture sauce beautifully. Avoid long pasta or tiny shapes that might become mushy during baking.

Is homemade pesto better than store-bought?

Homemade offers fresher, brighter basil flavor and lets you control ingredients. Quality store-bought pesto works perfectly for weeknight convenience—just check for pine nuts if serving guests with allergies.

What sides pair well with this casserole?

A crisp green salad with vinaigrette cuts through the richness. Roasted vegetables like broccoli or asparagus add nutrition. Garlic bread completes the comforting meal.

Baked Pesto Chicken Mac & Cheese

Comforting baked pasta with tender pesto chicken, three-cheese sauce, and crispy golden topping.

Prep Time
20 mins
Cook Time
35 mins
Total Duration
55 mins
Authored by Lana Bright

Recipe Type Hearty Dinners

Skill Level Medium

Cuisine Style American-Italian

Recipe Yield 6 Serving Size

Diet Preferences None specified

What You'll Need

Pasta

01 14 oz elbow macaroni

Chicken

01 1.1 lb boneless, skinless chicken breast, cut into bite-sized pieces
02 2 tbsp olive oil
03 1/2 tsp salt
04 1/4 tsp black pepper
05 1/2 tsp dried Italian herbs

Pesto

01 1/2 cup basil pesto

Sauce

01 3 tbsp unsalted butter
02 3 tbsp all-purpose flour
03 3 cups whole milk
04 1.5 cups shredded mozzarella cheese
05 1 cup shredded Parmesan cheese
06 1 cup shredded sharp cheddar cheese
07 1/2 tsp garlic powder
08 Salt and pepper to taste

Topping

01 1/2 cup panko breadcrumbs
02 1/4 cup grated Parmesan cheese
03 1 tbsp olive oil

Directions

Step 01

Prepare Baking Dish: Preheat oven to 400°F. Grease a 9x13 inch baking dish with butter or cooking spray.

Step 02

Cook Pasta: Bring a large pot of salted water to a boil. Add macaroni and cook until al dente according to package directions. Drain and set aside.

Step 03

Sear Chicken: Heat 2 tbsp olive oil in a skillet over medium heat. Add chicken pieces, season with salt, pepper, and Italian herbs. Cook for 6 to 8 minutes until golden and cooked through. Remove from heat and fold in basil pesto until evenly coated.

Step 04

Make Cheese Sauce: Melt butter in a large saucepan over medium heat. Whisk in flour and cook for 1 minute until fragrant. Gradually pour in milk while whisking constantly until the mixture thickens, approximately 4 to 5 minutes.

Step 05

Incorporate Cheeses: Remove saucepan from heat. Stir in mozzarella, Parmesan, cheddar, and garlic powder until fully melted and smooth. Adjust seasoning with salt and pepper.

Step 06

Combine Casserole: Transfer cooked macaroni to a large mixing bowl. Add the cheese sauce and pesto chicken. Gently fold together until all components are evenly distributed and coated.

Step 07

Transfer to Baking Dish: Pour the macaroni mixture into the prepared baking dish, spreading evenly to ensure uniform distribution.

Step 08

Prepare Topping: In a small bowl, combine panko breadcrumbs, grated Parmesan cheese, and olive oil. Mix until breadcrumbs are moistened. Distribute evenly over the casserole surface.

Step 09

Bake Casserole: Bake for 20 to 25 minutes until the casserole is bubbling at the edges and the breadcrumb topping turns golden brown.

Step 10

Rest and Serve: Remove from oven and let rest for 5 minutes before serving to allow the casserole to set slightly.

Tools You'll Need

  • Large pot for boiling pasta
  • Skillet for searing chicken
  • Large saucepan for creating cheese sauce
  • Mixing bowls
  • Whisk for sauce preparation
  • 9x13 inch baking dish
  • Measuring cups and spoons

Allergy Information

Review each ingredient to identify potential allergens, and consult a healthcare professional if you're unsure.
  • Contains gluten from pasta, flour, and panko breadcrumbs
  • Contains dairy including milk, cheese, and butter
  • May contain tree nuts such as pine nuts in commercial pesto
  • Verify all ingredient labels for potential cross-contamination

Nutrition Details (Per Serving)

This nutritional data is for reference only and isn't a substitute for medical advice.
  • Caloric Value: 620
  • Fats: 30 grams
  • Carbohydrates: 52 grams
  • Proteins: 36 grams