Cajun Chicken Alfredo Fettuccine

Featured in: Hearty Dinners

This dish combines juicy chicken breasts seasoned with Cajun spices and cooked to golden perfection. The fettuccine is tossed in a velvety Velveeta cheese sauce enriched with garlic, butter, and cream, delivering a rich, spicy flavor. Optional cayenne adds a subtle heat, balanced by fresh parsley and Parmesan. Quick to prepare, it's a creamy, comforting meal with a Southern flair that pairs beautifully with light salads or chilled wines.

Updated on Sat, 22 Nov 2025 16:43:00 GMT
A generous serving of Cajun Chicken Alfredo fettuccine pasta, creamy and coated in a cheesy sauce. Save It
A generous serving of Cajun Chicken Alfredo fettuccine pasta, creamy and coated in a cheesy sauce. | sunnyspoonful.com

A creamy, spicy pasta dish featuring tender Cajun-seasoned chicken, rich Velveeta cheese sauce, and perfectly cooked fettuccine—comfort food with a Southern twist.

I love making this dish on weekends because it's both quick and satisfying, and my family always asks for seconds.

Ingredients

  • Chicken: 2 large boneless skinless chicken breasts, 1 ½ tablespoons Cajun seasoning, 1 tablespoon olive oil
  • Pasta: 12 oz (340 g) fettuccine pasta
  • Sauce: 2 tablespoons unsalted butter, 2 cloves garlic minced, 1 cup (240 ml) heavy cream, 8 oz (225 g) Velveeta cheese cubed, ½ cup (50 g) grated Parmesan cheese, ½ teaspoon black pepper, ¼ teaspoon cayenne pepper (optional for extra heat), salt to taste
  • Garnish: 2 tablespoons fresh parsley chopped, extra grated Parmesan cheese (optional)

Instructions

Step 1:
Bring a large pot of salted water to a boil. Cook the fettuccine according to package instructions until al dente. Drain and set aside reserving ½ cup pasta water.
Step 2:
While the pasta cooks, pat chicken breasts dry. Rub both sides with Cajun seasoning.
Step 3:
In a large skillet, heat olive oil over medium-high heat. Add chicken and cook 5–6 minutes per side or until golden and cooked through (internal temperature 165°F/74°C). Remove chicken let rest 5 minutes then slice thinly.
Step 4:
In the same skillet reduce heat to medium. Add butter and garlic sauté 1 minute until fragrant.
Step 5:
Stir in heavy cream and bring to a gentle simmer. Add Velveeta cubes stirring often until melted and smooth.
Step 6:
Add Parmesan cheese black pepper and cayenne pepper (if using). Stir until fully combined and creamy. If sauce is too thick add reserved pasta water a little at a time.
Step 7:
Toss cooked fettuccine in the sauce until well coated.
Step 8:
Divide pasta among plates. Top with sliced Cajun chicken. Garnish with parsley and extra Parmesan if desired.
Sizzling, golden-brown Cajun chicken tops a mountain of flavorful Alfredo fettuccine pasta in this picture. Save It
Sizzling, golden-brown Cajun chicken tops a mountain of flavorful Alfredo fettuccine pasta in this picture. | sunnyspoonful.com

This meal always brings my family together around the table for a cozy dinner filled with laughter and good conversation.

Notes

Adjust Cajun seasoning for more or less heat. Substitute rotisserie chicken for a quicker version. Add sautéed bell peppers or mushrooms for extra flavor and color. Pairs well with a crisp green salad and a chilled Chardonnay.

Required Tools

Large pot, large skillet, knife and cutting board, tongs or pasta fork, measuring cups and spoons

Allergen Information

Contains milk/dairy (Velveeta Parmesan cream butter). Contains wheat (fettuccine). Contains chicken. Those with allergies should check ingredient labels for hidden allergens.

Imagine the rich Velveeta sauce over perfectly cooked fettuccine with the spicy Cajun Chicken Alfredo. Save It
Imagine the rich Velveeta sauce over perfectly cooked fettuccine with the spicy Cajun Chicken Alfredo. | sunnyspoonful.com

This Cajun Chicken Alfredo is the perfect balance of spicy and creamy, ideal for a comforting weeknight dinner.

Cajun Chicken Alfredo Fettuccine

Tender Cajun chicken and creamy Velveeta sauce coat fettuccine for a spicy Southern-inspired dish.

Prep Time
15 mins
Cook Time
25 mins
Total Duration
40 mins
Authored by Lana Bright

Recipe Type Hearty Dinners

Skill Level Easy

Cuisine Style American (Cajun-inspired)

Recipe Yield 4 Serving Size

Diet Preferences None specified

What You'll Need

Chicken

01 2 large boneless, skinless chicken breasts
02 1 ½ tablespoons Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 oz fettuccine pasta

Sauce

01 2 tablespoons unsalted butter
02 2 cloves garlic, minced
03 1 cup heavy cream
04 8 oz Velveeta cheese, cubed
05 ½ cup grated Parmesan cheese
06 ½ teaspoon black pepper
07 ¼ teaspoon cayenne pepper (optional)
08 Salt, to taste

Garnish

01 2 tablespoons fresh parsley, chopped
02 Extra grated Parmesan cheese (optional)

Directions

Step 01

Cook fettuccine: Bring a large pot of salted water to a boil. Add fettuccine and cook until al dente according to package instructions. Drain, reserving ½ cup pasta water, and set aside.

Step 02

Prepare chicken: Pat chicken breasts dry and rub evenly with Cajun seasoning on both sides.

Step 03

Sear chicken: Heat olive oil in a large skillet over medium-high heat. Cook chicken for 5 to 6 minutes per side until golden and internal temperature reaches 165°F (74°C). Remove from skillet and let rest for 5 minutes, then slice thinly.

Step 04

Make sauce base: Reduce heat to medium in the same skillet. Add butter and minced garlic; sauté for 1 minute until fragrant.

Step 05

Combine cream and cheese: Pour in heavy cream and bring to a gentle simmer. Add Velveeta cheese cubes and stir frequently until fully melted and smooth.

Step 06

Season sauce: Incorporate grated Parmesan, black pepper, cayenne pepper (if using), and salt to taste. Stir until evenly combined. If sauce thickens too much, gradually add reserved pasta water to reach desired consistency.

Step 07

Toss pasta with sauce: Add cooked fettuccine to the sauce and toss thoroughly to coat each strand.

Step 08

Serve with chicken and garnish: Divide pasta among plates. Top with sliced Cajun chicken. Garnish with chopped parsley and additional Parmesan cheese if desired.

Tools You'll Need

  • Large pot
  • Large skillet
  • Knife and cutting board
  • Tongs or pasta fork
  • Measuring cups and spoons

Allergy Information

Review each ingredient to identify potential allergens, and consult a healthcare professional if you're unsure.
  • Contains milk/dairy (Velveeta, Parmesan, cream, butter)
  • Contains wheat (fettuccine pasta)
  • Contains poultry (chicken)
  • Check labels for hidden allergens

Nutrition Details (Per Serving)

This nutritional data is for reference only and isn't a substitute for medical advice.
  • Caloric Value: 670
  • Fats: 32 grams
  • Carbohydrates: 57 grams
  • Proteins: 41 grams